UroToday.com - Until the development of androgen deprivation therapy (ADT), bilateral orchidectomy was the only way to achieve castration. Nowadays ADT can be considered a benchmark in the treatment of prostate cancer and it has been postulated that gonadotropin-releasing hormone (GnRH) agonists are able to reduce testosterone to obtain a level as low as bilateral orchidectomy. Different GnRH agonists are currently available.
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